Mrs. Hillerman has breast cancer. Her cancer cells secrete uncontrolled amounts of
parathyroid hormone-related peptide (PTHrP). She says, "Why are they drawing blood
again to measure calcium? Why is mine too low or too high?" ----Correct Answer------
Your blood calcium is too high because your cancer cells make a substance similar to
normal parathyroid hormone. Parathyroid hormone normally raises the blood calcium,
but a negative feedback system decreases its production when calcium levels start to
rise in the blood. The sub- stance your cancer cells make acts like parathyroid hormone
and raises blood calcium, but it is not controlled by negative feedback, and your cancer
cells are making too much of it.
Lipid-soluble hormone receptors are located: -----Correct Answer-------------Inside the
plasma membrane in the cytoplasm.
The releasing hormones that are made in the hypothalamus travel to the anterior
pituitary via the: -----Correct Answer-------------Portal hypophyseal blood vessels.
A student is observing in an endocrine clinic. "Why do these lab slips have a place to
request blood levels of carrier proteins for some hormones, such as thyroid, but not for
others such as ADH and ACTH?" ----Correct Answer------Some hormones, such as ADH
and ACTH, are water soluble and do not need carrier proteins in the blood. Thyroid
hormones and steroid hormones are not water soluble, so they need carrier proteins.
Thyroid-stimulating hormone (TSH) is released to stimulate thyroid hormone (TH) and is
inhibited when plasma levels of TH are adequate. This is an example of: -----Correct
Answer-------------Negative feedback. Feedback systems provide precise monitoring and
control of the cellular environment. Negative feedback occurs because the changing
chemical, neural, or endocrine response to a stimulus negates the initiating change that
triggered the release of the hormone.
Which mineral is needed for thyroid-stimulating hormone (TSH) to stimulate the
secretion of thyroid hormone (TH)? -----Correct Answer-------------Iodide.
What effect does hyperphosphatemia have on other electrolytes? -----Correct Answer---
----------Decreases serum calcium.
How does a faulty negative-feedback mechanism result in a hormonal imbalance?
a. Hormones are not synthesized in response to cellular and tissue activities.
b. Decreased hormonal secretion is a response to rising hormone levels.
c. Too little hormone production is initiated.
d. Excessive hormone production results from a failure to turn off the system. ----Correct
Answer------Excessive hormone production results from a failure to turn off the system.
[Negative-feedback systems are important in maintaining hormones within physiologic
ranges. The lack of negative-feedback inhibition on hormonal release often results in
pathologic conditions. Excessive hormone production, which is the result of the failure to
turn off the system, can cause various hormonal imbalances and related conditions. The
correct option is the only accurate description of this hormonal function.]
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